Woods,J., Jones,L. W. Pilot study to determine the effect of lens and eye rinsing on Solution-Induced Corneal Staining (SICS). Optometry and Vision Science 2016;93,10:1218-1227. [ Show Abstract ]
Purpose The main purpose of this study was to determine whether two interventions (rinsing the lens before lens insertion and rinsing the ocular surface post-lens removal) had any impact on solution-induced corneal staining (SICS). In addition, the presence of hyper-reflective epithelial cells in the presence of SICS was investigated. Methods Twenty subjects wore new balafilcon A lenses, which had been soaked overnight in a multipurpose care product containing polyhexamethylene biguanide for 2 hours. The study was conducted across three phases. In phase 1 (investigator and subject masked, randomized eye), one lens was rinsed with nonpreserved saline before lens insertion. In phase 2 (investigator masked, randomized eye), one eye was rinsed with nonpreserved saline after lens removal, before staining assessment. Corneal staining was recorded as the percentage area of the cornea exhibiting superficial punctate staining. In both phases, ocular comfort and presence of specific symptoms were captured. In phase 3, there was no randomized treatment; confocal images of the epithelium were obtained after 2 hours of wear. Results In phase 1 (lens-rinse), there was no significant difference in staining between the treated and untreated eyes (84 vs. 92%, respectively; p = 0.06). In phase 2 (eye-rinse), there was also no significant difference between the treated and untreated eye (86 vs. 86%, p = 0.92). Most subjects were asymptomatic. In phase 3, images of hyper-reflective cells were captured in 97% of the eyes imaged. Conclusions The two rinsing procedures did not affect the level of the SICS response. Hyper-reflective epithelial cells were found to be present in a significant number of eyes exhibiting SICS, and their presence warrants further investigation. Â© 2016 American Academy of Optometry.
Liu,S., Chang,C. N., Verma,M. S., Hileeto,D., Muntz,A., Stahl,U., Woods,J., Jones,L. W., Gu,F. X. Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentallyinduced dry eye syndrome. Nano Research 2015;8,2:621-635.
Woods,J., Guthrie,S. E., Keir,N., Dillehay,S., Tyson,M., Griffin,R., Choh,V., Fonn,D., Jones,L., Irving,E. Inhibition of defocus-induced myopia in chickens. Investigative Ophthalmology and Visual Science 2013;54,4:2662-2668. [ Show Abstract ]
PURPOSE. To determine the effect of wearing a lens with a unique peripheral optical design on the development and progression of defocus-induced myopia in newly hatched chickens.METHODS. Eighty-five newly hatched chickens underwent bilateral retinoscopy and A-scan ultrasound to determine their refractive error and axial length. They were randomly divided into Control and two Test groups, in which each chicken was fitted with a goggle-lens over the right eye, with the left eye remaining untreated. The Control group wore a lens of power - 10.00 diopters (D) of standard spherical optical design. The two Test lenses both had a central optical power -10.00 D, but used different peripheral myopia progression control (MPC) designs. For all groups, retinoscopy was repeated on days 3, 7, 10, and 14; ultrasound was repeated on day 14.RESULTS. On day 0 there was no statistical difference in refractive error (mean +6.92 D) or axial length (mean 8.06 mm) between Test and Control groups or treated and untreated eyes (all P > 0.05). At day 14, 37 (43.5%) of 85 chickens had not experienced goggle detachment and were included in the final analyses. In this cohort there was a significant refractive difference between the treated eyes of the Control group (n = 17) and those of Test 1 (n = 14) and Test 2 (n = 6) groups (both P < 0.01): Control -4.65 ± 2.11 D, Test 1 +4.57 ± 3.11 D, Test 2 +1.08 ± 1.24 D (mean ± SEM). There was also a significant axial length difference (both P < 0.01): Control 10.55 ± 0.36 mm, Test 1 9.99 ± 0.14 mm, Test 2 10.17 ± 0.18 mm.CONCLUSIONS. Use of these unique MPC lens designs over 14 days caused a significant reduction in the development of defocus-induced myopia in chickens; the degree of reduction appeared to be design specific. © 2013 The Association for Research in Vision and Ophthalmology, Inc.
Woods,J., Jones,L., Woods,C., Schneider,S., Fonn,D. Use of a photographic manipulation tool to assess corneal vascular response. Optometry and Vision Science 2012;89,2:215-220. [ Show Abstract ]
Purpose. Corneal vasculature change in contact lens wearers has been linked to the level of hypoxia within the cornea. To assess the impact a treatment has on limbal vessels, a sensitive method of measurement and quantification is required. Methods. A group of 21 highly myopic, hydrogel wearers, with preexisting signs of corneal hypoxia, were enrolled into a study where they wore sifilcon A silicone hydrogel lenses (Dk/t = 117), on a daily wear basis for 9 months. At all scheduled visits, photographs were taken of the superior, inferior, temporal, and nasal limbal regions which were then imported into Adobe Photoshop. A red-free filter was applied to enhance the contrast of the blood columns. In each quadrant, the length of the longest visible blood column was measured and the blood columns that penetrated -0.5 mm into the cornea were counted. A control group of 11 non-lens wearers was recruited. Their photographs were taken at the beginning of the study and 9 months later. An independent, masked observer assessed the photographs. Results. There was a significant decrease in the maximum penetration of the blood column in all quadrants (p + 0.001) from baseline to the 9-month visit (e.g., superior: baseline 0.84 ± 0.39 mm; 9 months 0.63 ± 0.20 mm). There was also significant reduction in the number of visible blood columns longer than 0.5 mm in each quadrant (p + 0.001) from baseline to 9 months in all quadrants (e.g., superior: baseline 14.0 ± 8.2; 9 months 6.5 ± 6.0). The control group showed no change over time for the maximum blood column length (p = 0.638) or the number of columns >0.5 mm (p = 0.341). Conclusions. A group of highly myopic subjects exhibited reduction in the maximum length and number of blood columns in the cornea when refit with a highly permeable silicone hydrogel material. The use of photography, along with Adobe Photoshop software, provides a reliable way of measuring corneal vascular responses over time. (Optom Vis Sci 2012;89:215-220). © 2012 American Academy of Optometry.
Woods,J., Woods,C. A., Fonn,D. Early symptomatic presbyopes-What correction modality works best?. Eye and Contact Lens 2009;35,5:221-226. [ Show Abstract ]
Purpose: To compare the performance of a low-addition silicone hydrogel multifocal soft lens with other soft lens correction options in a group of habitual soft lens wearers of distance correction who are symptomatic of early presbyopia. METHOD: This clinical study was designed as a prospective, double-masked, randomized, crossover, dispensing trial consisting of four 1-week phases, one for each of the correction modalities: a low-addition silicone hydrogel multifocal soft lens, monovision, habitual correction, and optimized distance visual correction. The prescriptions of all modalities were finalized at a single fitting visit, and the lenses were worn according to a randomized schedule. All lenses were made from lotrafilcon B material. A series of objective vision tests were conducted: high- and low-contrast LogMAR under high- and low-room lighting conditions, stereopsis, and critical print size. A number of other data collection methods used were novel: some data were collected under controlled laboratory-based conditions and others under "real-world" conditions, some of which were completed on a BlackBerry hand-held communication device. RESULTS: All participants were able to be fit with all four correction modalities. Objective vision tests showed no statistical difference between the lens modalities except in the case of low-contrast near LogMAR acuity under low-lighting levels where monovision (+0.29 ± 0.10) performed better than the multifocal (+0.33 ± 0.11, P=0.027) and the habitual (+0.37 ± 0.12, P<0.001) modalities. Subjective ratings indicated a statistically better performance provided by the multifocal correction compared with monovision, particularly for the vision associated with driving tasks such as driving during the daytime (93.3 ± 8.8 vs. 84.2 ± 23.7, P=0.05), at nighttime (88.8 ± 11.7 vs. 74.9 ± 23.6, P=0.001), any associated haloes or glare (92.0 ± 10.6 vs. 78.0 ± 22.8, P=0.003), and observing road signs (90.1 ± 11.8 vs. 79.4 ± 20.2, P=0.027). Preference for the multifocal compared with monovision was also reported when watching television (95.0 ± 6.4 vs. 82.6 ± 20.1, P=0.001) and when changing focus from distance to near (87.0 ± 13.4 vs. 66.1 ± 32.2, P<0.001). CONCLUSIONS: For this group of early presbyopes, the AIR OPTIX AQUA MULTIFOCAL-Low Add provided a successful option for visual correction, which was supported by the results of subjective ratings, many of which were made during or immediately after performing such activities as reading, using a computer, watching television, and driving. These results suggest that making a prediction of "success or not" based on consulting room acuity tests alone is probably unwise. Copyright © Contact Lens Association of Ophthalmologists, Inc.
Subbaraman,L. N., Woods,J., Teichroeb,J. H., Jones,L. Protein deposition on a lathe-cut silicone hydrogel contact lens material. Optometry and Vision Science 2009;86,3:244-250. [ Show Abstract ]
PURPOSE: To determine the quantity of total protein, total lysozyme, and the conformational state of lysozyme deposited on a novel, lathe-cut silicone hydrogel (SiHy) contact lens material (sifilcon A) after 3 months of wear. METHODS: Twenty-four subjects completed a prospective, bilateral, daily-wear, 9-month clinical evaluation in which the subjects were fitted with a novel, custom-made, lathe-cut SiHy lens material. The lenses were worn for three consecutive 3-month periods, with lenses being replaced after each period of wear. After 3 months of wear, the lenses from the left eye were collected and assessed for protein analysis. The total protein deposited on the lenses was determined by a modified Bradford assay, total lysozyme using Western blotting and the lysozyme activity was determined using a modified micrococcal assay. RESULTS: The total protein recovered from the custom-made lenses was 5.3 +/- 2.3 microg/lens and the total lysozyme was 2.4 +/- 1.2 microg/lens. The denatured lysozyme found on the lenses was 1.9 +/- 1.0 microg/lens and the percentage of lysozyme denatured was 80 +/- 10%. CONCLUSIONS: Even after 3 months of wear, the quantity of protein and the conformational state of lysozyme deposited on these novel lens materials was very similar to that found on similar surface-coated SiHy lenses after 2 to 4 weeks of wear. These results indicate that extended use of the sifilcon A material is not deleterious in terms of the quantity and quality of protein deposited on the lens.
Fonn,D., Simpson,T., Woods,J., Woods,C. New technologies to assess lens-mediated effects of the cornea. Eye and Contact Lens 2007;33,6 PART 2 OF SUPPL 2:364-370. [ Show Abstract ]
Contact lenses can affect the cornea in a variety of ways. Corneal structure can be altered so that its thickness changes to involve the epithelium and the stroma. As a result, the curvature may be affected, but whether it is the front or the back surface that is affected depends on the type of lens used. If thickness increases sufficiently, corneal transparency may decrease. Contact lenses can also affect cellular structure of all layers of the cornea through mechanical trauma, hypoxia, or toxicity from solutions that are used in association with lenses. More serious complications, such as inflammation and infection, can arise. All these changes can be detected by clinicians using slitlamp biomicroscopes and keratometers if the changes are significant enough. Since the development of computers, optical instruments have become more sophisticated and have enabled the detection of subtle changes but have also facilitated more precise measurement of these conditions along with the ability to capture images of the alterations or defects. This article describes some of the newer techniques and, specifically, the application of optical coherence tomography, confocal microscopy, and esthesiometry. © 2007 Lippincott Williams & Wilkins, Inc.
Yang M, Luensmann D, Fonn D, Woods J, Gordon K, Jones L, Jones D. Myopia prevalence in canadian school children. Optom Vis Sci 2016;93: E-abstract 165328. [ PDF ]
Chamberlain P, Back A, Woods J, Logan N, Peixoto-de-Matos S, Mei Sae S, Young G. Wearer experience and subjective responses with a dual focus myopia control 1 day soft contact lens. Optom Vis Sci 2016;93: E-abstract 165326.
Guthrie S, Woods J, Dumbleton K, Fonn D, Jones L. Contact lens discomfort management strategies of ECPs. Optom Vis Sci 2015;92: E-abstract 155050. [ PDF ]
Panjwani F, Papinski D, Woods J, Jones L. In-vivo dehydration of omafilcon A and delefilcon A. Optom Vis Sci 2015;92: E-abstract 155048. [ PDF ]
Panjwani F, Papinski D, Varikooty J, Woods J, Jones L. In-vivo dehydration of stenfilcon A and delefilcon A silicone hydrogel materials. Optom Vis Sci 2015;92: E-abstract 155262. [ PDF ]
Dillehay S, Woods J, Situ P, Guthrie S, Paynor R, Griffin R, Tyson M, Jones L. Comparison of Three Power Levels of A Novel Soft Contact Lens Optical Design to Reduce Suspected Risk Factors for the Progression of Juvenile Onset Myopia. Invest Ophthalmol Vis Sci 2014;55: E-abstract 3637.
Payor R, Woods J, Fonn D, Situ P, Dillehay S, Griffin R, Tyson M, Jones L. Feasibility Testing of a Novel Soft Contact Lens Optical Design to Reduce Suspected Risk Factors for the Progression of Juvenile Onset Myopia. Invest Ophthalmol Vis Sci 2014;55: E-abstract 3638.
Liu S, Chang C, Verma M, Hileeto D, Muntz A, Stahl U, Woods J, Jones L, Gu F. Phenylboronic acid modified mucoadhesive nanoparticles facilitate weekly treatment of dry eye syndrome. Invest Ophthalmol Vis Sci 2014;55: E-abstract 2160.
Varikooty J, Woods J, Jones L. Assessment of pre-lens tear film particle velocity measurements in participants wearing daily disposable silicone hydrogel lenses. BCLA Clinical Conference and Exhibition, 2014. [ PDF ]
Feng W, Woods J, Keir N, Chamberlain P. Subjective questionnaire data collection using two different scales. Optom Vis Sci 2014;91: E-abstract 145054.
Woods J, Subbaraman L, Jones L. In-vitro wettability of four silicone hydrogel lenses with differing surface properties. Contact Lens & Anterior Eye 2013;36,S2:e29.
Woods J, Woods C, Foon D, Jones L. Acceptance of a silicone hydrogel multifocal lens in emmetropic presbyopes. Canadian Optometry Schools Research Conference, Waterloo, Canada, 2013.
Dumbleton K, Woods CA, Woods J, Moezzi A, Fonn D, Jones L. An Investigation Into The Role Of Masked Lens Replacement On Subjective Comfort And Vision With Aging Soft Contact Lenses . Invest Ophthalmol Vis Sci 2012;53:ARVO E-Abstract 4722.
Woods J, Keir N, Jones L. Solution-induced-corneal-staining (SICS): symptoms and staining patterns. Optom Vis Sci 2012;89:E-abstract 125625.
Woods J, Keir N, Jones L. The impact of saline rinsing on solution-induced corneal staining (SICS). Contact Lens & Anterior Eye 2012;35,S1:e36-e37.
Guthrie S, Woods J, Keir N, Dillehay S, Tyson M, Griffin R, Fonn D, Jones L, Irving E. Controlling lens induced myopia in chickens with peripheral lens design. Optom Vis Sci 2011;88:E-Abstract 110421.
Woods J, Guthrie S, Keir N, Choh V, Fonn D, Jones L, Irving E. Myopia development – what can the chicken tell us?. Contact Lens & Anterior Eye 2011;34,Supplement 1:s13.
Woods J, Guthrie S, Keir N, Dillehay S, Tyson M, Griffin R, Jones L, Irving E. The effect of a unique lens designed for myopia progression control (MPC) on the level of induced myopia in chicks. Invest Ophthalmol Vis Sci 2011;51:E-Abstract 6651.
Woods J, Woods CA, Fonn D. Using objective tests and novel subjective rating assessments to compare the performance of a new silicone hydrogel multifocal lens design to monovision. Contact Lens & Anterior Eye 2009;32,5:232.
Woods J, Schneider S, Woods CA, Fonn D. Application of a novel method for evaluating corneal vascularization. Optom Vis Sci 2008;85: E-Abstract 80083.
Woods J, Woods CA, Fonn D. Comparison of the simplicity of completing an initial fit of symptomatic early presbyopes with monovision and an aspheric multifocal silicone hydrogel. Optom Vis Sci 2008;85: E-Abstract 80089.
Jones L, Subbaraman L, Woods J. Protein deposition on a novel lathe-cut silicone hydrogel contact lens material (sifilcon A). Contact Lens & Anterior Eye 2008;31,5:262.
Subbaraman L, Woods J, Jones L. Protein deposition on a novel lathe-cut silicone hydrogel contact lens material (sifilcon A). Optom Vis Sci 2007;84:E-abstract 070038.
Dumbleton K, Woods J, Woods C, and Fonn D. Compliance with current contact lens care regiments. Optom Vis Sci 2007;84: E-abstract 070087.
Woods J, Schneider S, Woods CA, Jones LW, Fonn D. Short term satisfaction and physiological response in wearers of high power hydrogel lenses refit with a custom silicone hydrogel lens. Optom Vis Sci 2007;84: E-abstract 070034.
Woods J, Woods CA. Vision test that discriminates multifocal contact lenses. BCLA Clinical Conference and Exhibition, 2007.
Woods J, Woods C, Varikooty J, Jones L, Simpson T, Fonn D. A novel method of recording corneal staining that facilitates parametric analysis. Optom Vis Sci 2006;83: E-Abstract 065236.
Woods C, Scott M, Woods J, Simpson T, Fonn D. Clinical grading scales: how many images is ideal?. Contact Lens & Anterior Eye 2006;29,4:207.
Woods C, Scott M, Woods J, Simpson T, Fonn . A novel method to create clinical grading scales. Optom Vis Sci 2005;82: E-abstract 050040.
Woods J. Conjunctival Responses to Contact Lens Wear. Contact Lens Spectrum 2015;30,August:34-36, 38.
Woods J, Woods C, Fonn D, Jones L. Potential acceptance of a daily disposable silicone hydrogel multifocal lens in emmetropic presbyopes. Optom Vis Sci 2013;88: E-Abstract 135100.
Woods J, Woods CA, Fonn D. Managing the emerging presbyopic contact lens wearer. Optometry Today 2009;49,12:32-35.
Woods J, Woods C, Fonn D. Practical guide for fitting soft centre near design multifocal contact lenses. Contact Lens Spectrum 2009.
Jones L, Dumbleton K, Woods J. A made-to-ofer silicone hydrogel lens. Optician 2007;233,6104:45-47.
Jones L, Dumbleton K, Woods J. Fitting a challenging case with a custom silicone hydrogel. Contact Lens Spectrum 2007;22,6:17.
Jones L, Dumbleton K, Woods J. Fitting and evaluating a custom silicone hydrogel lens. Contact Lens Spectrum 2007;22,4:19.
Jones L, Dumbleton K, Woods J. Introducing a made-to-order silicone hydrogel lens. Contact Lens Spectrum 2007;22,2:23.
Jones L, Dumbleton K, Woods J. A made to order silicone hydrogel lens. Optician 2007;233,6104:45-47.